Anti-GBM/Anti-TBM nephritis treatment

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How it works

Consult with our health coaches who will learn about your symptoms, habits, and goals.


Take personalized home health tests to discover potential root causes of any symptoms or conditions you may have.


Review your results in just days with our functional medicine doctors, nurses, and dietitians who will help you achieve optimal health.

Learn about Anti-GBM/Anti-TBM nephritis

Anti-GBM/Anti-TBM nephritis, also known as Anti-Glomerular Basement Membrane Disease or Goodpasture's Syndrome, is a rare autoimmune disorder that attacks the kidneys and lungs. This condition can lead to serious complications, including kidney failure and pulmonary hemorrhage. Although its prevalence is low, with an estimated incidence of approximately 1 case per million people annually, the impact of Anti-GBM/Anti-TBM nephritis on affected individuals can be profound.


The exact cause of Anti-GBM/Anti-TBM nephritis is not fully understood. It occurs when the body's immune system mistakenly produces antibodies against the glomerular basement membrane (GBM), a key component of the kidneys' filtering units, and sometimes against the lungs' alveolar basement membrane (TBM). This autoimmune response can be triggered by various factors, including viral infections, exposure to certain chemicals, or a genetic predisposition.


Signs and symptoms

- Fatigue - Nausea - Weakness - Difficulty breathing - High blood pressure - Blood in urine (hematuria) - Protein in urine (proteinuria) - Reduced kidney function It's crucial to recognize these symptoms early, as prompt diagnosis and treatment can significantly affect the outcome.

Diagnosing Anti-GBM/Anti-TBM nephritis

Diagnosis of Anti-GBM/Anti-TBM nephritis involves a combination of clinical assessment, blood tests, and kidney biopsy. Blood tests can detect antibodies against the GBM and TBM, confirming the autoimmune nature of the disease. A kidney biopsy is often performed to assess the extent of kidney damage and to distinguish Anti-GBM/Anti-TBM nephritis from other kidney diseases.


Prevention and natural treatment

Preventing Anti-GBM/Anti-TBM nephritis involves minimizing exposure to potential triggers, such as organic solvents and cigarette smoke, especially in individuals with a known susceptibility. Regular health check-ups can also help in early detection, making treatment more effective. In terms of treatment, conventional approaches include medications that suppress the immune system, such as corticosteroids and cyclophosphamide, and plasmapheresis to remove antibodies from the blood. Functional medicine offers complementary strategies focusing on enhancing overall health. This includes dietary modifications to reduce inflammation, such as increasing the intake of omega-3 fatty acids and antioxidants found in fruits and vegetables. Nutritional supplements, like N-acetylcysteine (NAC), may help in reducing oxidative stress. Stress management techniques, such as yoga and meditation, can also play a role in treatment by reducing the overall burden on the immune system. It's important to have a comprehensive approach that includes close monitoring by healthcare professionals, as natural treatments alone may not be sufficient for all patients. While there is no current cure for Anti-GBM/Anti-TBM nephritis, combining functional medicine approaches with conventional treatments can help manage symptoms and improve quality of life.

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