Evans syndrome treatment

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How it works
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Consult with our health coaches who will learn about your symptoms, habits, and goals.

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Take personalized home health tests to discover potential root causes of any symptoms or conditions you may have.

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Review your results in just days with our functional medicine doctors, nurses, and dietitians who will help you achieve optimal health.

Learn about Evans syndrome

Evans syndrome is a rare autoimmune disorder, where the body’s immune system mistakenly attacks and destroys its own blood cells, including red blood cells, platelets, and sometimes white blood cells. This leads to a combination of symptoms stemming from hemolytic anemia, due to the reduction of red blood cells, and thrombocytopenia, due to the decrease in platelets. It is a chronic condition that can affect individuals of any age, but it has varying levels of prevalence in different age groups and is relatively rare in the general population.

Causes

The exact causes of Evans syndrome remain largely unknown. It is classified as an autoimmune disorder, which means it results from the immune system attacking the body's own cells. In the case of Evans syndrome, the immune system produces antibodies that target and destroy the body's red blood cells and platelets. Some cases appear to be linked to underlying autoimmune conditions, malignancies, or infections, suggesting that these could trigger or exacerbate the immune response against blood cells.

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Signs and symptoms

- Unexplained bruises or bleeding due to low platelet count - Fatigue or weakness as a result of anemia - Jaundice (yellowing of the skin and eyes) due to the rapid breakdown of red blood cells - Dark urine, a result of the body disposing of the byproducts of destroyed red blood cells - An enlarged spleen (splenomegaly) - Frequent infections if white blood cells are affected

Diagnosing Evans syndrome

Diagnosis of Evans syndrome is primarily based on the clinical presentation of concurrent autoimmune hemolytic anemia and immune thrombocytopenia without a clear cause. Blood tests are essential for measuring the levels of red blood cells, white blood cells, and platelets. Direct antiglobulin (Coombs) tests can help identify antibodies that are causing the destruction of red blood cells. Due to the rarity and complexity of Evans syndrome, diagnosis may also include ruling out other conditions that might cause similar symptoms.

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Prevention and natural treatment

Preventing Evans syndrome is challenging due to its unclear causes. However, identifying and managing underlying conditions that might trigger the autoimmune response is a critical step. In terms of treatment, functional medicine approaches focus on improving overall immune system function and reducing inflammation, alongside conventional treatments. Nutritional therapy, aimed at correcting potential deficiencies and supporting immune health, is vital. Omega-3 fatty acids, vitamin D, and antioxidants like vitamin E and selenium can play supportive roles. Conventional treatment often utilizes steroids to suppress the immune system’s activity against blood cells, alongside other immunosuppressive drugs or biological agents targeting specific immune pathways. In some cases, splenectomy (removal of the spleen) is considered if medications do not sufficiently control the condition. Functional medicine also emphasizes the importance of gut health in autoimmune conditions, suggesting that a healthy gut microbiome may modulate immune responses. Probiotics, prebiotics, and a diet rich in whole foods can support this aspect of treatment. Lastly, stress management practices like meditation, yoga, and adequate sleep can further aid in modulating the immune system. Each treatment plan should be personalized, taking into account the patient's specific symptoms, health status, and response to previous treatments. Collaboration between healthcare providers, including functional medicine practitioners, can offer a comprehensive, holistic approach to managing Evans syndrome.

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